A recent study  has shown that men who took testosterone replacement over 8-10 years had decreased risk of heart attacks and death. The average age was 61 and these men had starting levels less than 349. So these are men at the prime age of having heart attacks. There were 656 men in the study in which 360 men chose to have testosterone replacement and 296 decided not to have testosterone. Results were 26 nonfatal MIs and 30 nonfatal strokes in the control group and none in the testosterone-treated group!!! Of the 329 treatment group none had died from cardiovascular events. However in the non-treatment group 19 died due to cardiovascular events!
So what led to the testosterone having such an improvement in cardiovascular disease? The reason is that many risk factors for cardiovascular disease are significantly reduced with testosterone replacement. A significant improvement was seen in waist circumference, body weight, BMI, systolic and diastolic blood pressure, LDL, HDL, triglycerides and non-HDL, glycemic control and liver enzymes. Particularly notable are the marked reductions in non-HDL from 224 to 113 mg and HbA1c 6.9% to 5.6% in testosterone treated men, compared to increases in non-HDL and HbA1c from 194 to 201 and 6.1% to 6.4% respectively, in non-treated men.
Another interesting finding was in the testosterone treated patients 1.9% were diagnosed with low-grade prostate cancer. However, in the untreated group there were more patient diagnosed with prostate cancer (4.1%)
1. Traish, A., et al., Long-Term Testosterone Therapy Improves Cardiometabolic Function and Reduces Risk of Cardiovascular Disease in Men with Hypogonadism: A Real-Life Observational Registry Study Setting Comparing Treated and Untreated (Control) Groups. Journal of Cardiovascular Pharmacology and Therapeutics, 2017: p. epub.
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